Outlook?for?research?Studying?the?capabilities?and?survival?strategies?of?insects?and?leveraging?them?in?daily?lifeOutlook?for?research?Understanding?the?nature?of?stem?cells?and?controlling?their?fate51応用生物科学科Department?of?Applied?Biology応用生物科学科Department?of?Applied?BiologyOutlookforstudentsaftergraduationOutlookforstudentsaftergraduationInsectsarethemostprosperousanimalsontheearth.Theyemployartfulsurvivalstrategiestoadapttotheenvironment,andeachspecieshasdevelopeduniquefeatures.Iinvestigateattractiveandusefulcapabilitiesofinsectsinordertoleveragethemtobenefitourdailylivesinthefuture.Insectsarenotcompletelydifferentfromus,afactthatisclearevenifweonlyconsidertheirmorphology.Researchintothespecialfeaturesofinsectsprovidesuswithimportantcluestounderstandingourselvesashumans.Thepicturetotherightshowsagreenlarva.Inthislarva,dye‐bindingproteinsarestoredingranulesinepidermalcells.Mylabisresearchingthemechanismbywhichthesegranulesareformed.Bydiscoveringhowthatoccurs,wehopetoalsodiscoveramechanismbywhichsecretoryproteinscanbemaintainedwithincells.Graduates?are?active?as?researchers?at?food?and?pharmaceutical?manufacturers?and?as?public?officials.AssociateProfessorKojiShiraiAssociateProfessorShiraitookhiscurrentpositionafterworkingasaCOEspecialresearcherattheNationalInstituteofSericulturalandEntomologicalScienceoftheMinistryofAgriculture,Forestry,andFisheriesandasanassistantprofessoratShinshuUniversity.Hisareasofspecializationarebiologicalchemistryandmolecularcellbiologyforutilizinginsectsandinsectcells.Thegreenlarvaofthesweetpotatohornworm,Agriusconvolvuli,alargelepidopteraninsectfoundthroughoutJapan.Adye‐bindingproteinextractedfromthedermalcellofaninsect.Theproteincontainscluesaboutproteinsecretioncontrol.ThespermatogenicpotentialofGScellsisexpectedtofindapplicationnotonlyintreatingmaleinfertility,butalsoinproducingsuperiorlivestock.Inaddition,mGScellsareexpectedtoserveasanothersourceofpluripotentstemcellssuchasiPScells.Inthiscontext,GScellsmightbecalledmultipotentstemcellswiththepotentialtocontributetoawiderangeoffields.Thevalueofthemarketassociatedwithregenerativemedicineisexpectedtogrowto1trillionyenin2020(accordingtostatisticsfromtheMinistryofEconomy,TradeandIndustry).Itismyhopethatourfuturecolleagueswillbeabletoplayaremarkableroleingrowthindustries,includinginregenerativemedicine.RegenerativemedicineusingiPScellsisexpectedtoserveasanovelapproachforcuringdisease.Mylabisfocusingongermlinestem(GS)cells,tissue‐specificstemcellsintestis.AlthoughGScellshavealreadycommittedtogermcelllineage,theyalsohavepluripotencypotentialandoftende‐differentiateintomultipotentGS(mGS)cellsthatpossesspluripotencylikeiPScells.ThegoalofourresearchistounderstandtheuniquenatureofGS/mGScellsandcontroltheirfate.AssociateProfessorSeijiTakashimaAfterreceivingadoctorate(inengineering)fromTokyoInstituteofTechnology,AssociateProfessorTakashimaworkedasaresearchfellowattheUniversityofTokyobeforecomingKyotoUniversityasanassistantprofessor.Hisareasofresearchareregenerativemedicineandstemcellbiology.GScells.Left:MouseGScellsgrowinginvitro.Center:SpermatogenesisinthetestistransplantedwithGScellsexpressinggreenfluorescentprotein(GFP).Right:MouseoffspringproducedfromspermderivedfromGScellsexpressingGFP.TheoffspringalsoexhibitedgreenfluorescenceunderUVlight.ThepluripotencypotentialofGScells.Left:mGScellsde‐differentiated(rejuvenated)fromGScells.mGScellspossesspluripotencylikeiPScells.Right:mGScancontributetotheformationof“chimeramice.”mGS‐derivedtissueinthechimaeramiceexhibitedGFPexpression.
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